Managing Sjögren’s Syndrome and non-Sjögren Syndrome dry eye with anti-inflammatory therapy

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Managing Sjögren’s Syndrome and non-Sjögren Syndrome dry eye with anti-inflammatory therapy

Dry eye from Sjögren's syndrome is a multifactorial disease that results in dysfunction of the lacrimal functional unit. Studies have shown changes in tear composition, including inflammatory cytokines, chemokines, and metalloproteinase. T-lymphocytes have been shown to increase in the conjunctiva and lacrimal glands in patient and animal models. This inflammation is in part responsible for the...

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CONTEXT Postmenopausal hormone replacement therapy (HRT) use is common in the United States. Some research suggests that estrogen may have detrimental effects on the tear film and could influence the development of dry eye syndrome, but few data are available on this relationship. OBJECTIVE To determine the relationship of HRT and dry eye syndrome. DESIGN, SETTING, AND PARTICIPANTS The Wome...

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Dry Eye Syndrome

Our understanding of keratoconjunctivitis sicca (KCS), also known as dry eye syndrome, has been changed over recent years. Until lately, the condition was thought to be merely due to aqueous tear insufficiency. Today, it is understood that KCS is a multifactorial disorder due to inflammation of the ocular surface and lacrimal gland, neurotrophic deficiency and meibomian gland dysfunction. This ...

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Dry eye and Meige's syndrome.

AIMS To determine the relation between dry eye and Meige's syndrome. METHODS 325 patients with dry eye were divided into those responsive to topical and other forms of treatment (n = 276) and those who were not (n = 49). A neuropsychiatric examination was performed to check for Meige's syndrome in the latter group. RESULTS Twenty eight (57%) of the treatment unresponsive patients were diagn...

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dry eye syndrome

purpose: dry eye syndrome is a multifactorial disorder of the tear film and ocular surface that results in eye discomfort, visual disturbance, and often ocular surface damage. studies suggest that the prevalence of clinically diagnosed dry eye syndrome (des) is 0.4%. to 0.5%, which is highest among women and the elderly. the burden of des can be substantial, affecting visual function, daily act...

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ژورنال

عنوان ژورنال: Clinical Ophthalmology

سال: 2014

ISSN: 1177-5483

DOI: 10.2147/opth.s35685